Star Wars Knights of the Old Republic II: The Sith Lords

What can I do as a last resort if the program will just not run?

If you are still encountering issues with getting the game to run, there is one last thing you can try which may help resolve certain graphics issues if all else fails. Edit your "swkotor2.ini" file and locate the (Graphics Options) section. Add a new line which includes the following statement:

Disable Vertex Buffer Objects=1